When 70-year-old Peter Els’s dog dies, 911 responders arrive at his home and discover a room converted into an amateur biochemical engineering lab. Orfeo, National Book Award winner Powers’s novel inspired by the Greek myth of Orpheus, follows Els, a onetime adjunct professor, as he flees from the ensuing federal investigation and along the way visits his estranged family members; in flashbacks, Powers tells the story of a man so entranced by the act of creation—first of music, then of biochemical processes—that it has isolated him from much of the world.